Metabolic Syndrome – The Science of Obesity and Fat Cells
New therapeutic approaches for Metabolic syndrome by analyzing Epigenome and metabolome.
Obesity and various metabolic disturbance including type 2 diabetes, insulin resistance, atherosclerosis and lipid disorders are epidemic health problem in 21 centuries. These disorders are also called “lifestyle diseases” and closely related to the environmental cue as well as genetic background. Environmental stimuli are recorded on DNAs and histones as chemical modification such as methylation and epigenomic changes are closely related to the development of lifestyle diseases. We are currently trying to reveal alterations of epigenome by environment and nutritional cue such as cold exposure or fasting that may lead to the new therapy for lifestyle disease .
Epigenome that is transmitted to offspring.
It has been known that paternal exposure to cold environmental temperature prior to reproduction results in offspring exhibiting greater energy consumption and heat generation. These traits counteract the deleterious effects of overnutrition, such as obesity and metabolic syndrome. Using single-cell analyses, we will elucidate mechanisms of epigenetic memory in the central nervous system-adipose axis that mediate adaptation to cold. We will identify and manipulate candidate genes in a cell-type-specific manner in mice. We will confirm our studies in humans by analyzing relationships between thermogenic brown adipose tissue activity assessed as fluorodeoxyglucose-positron emission tomography and paternal environment.
Juro SAKAI ／ SAKAI Laboratory